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Mining Significant Substructure Pairs for Interpreting Polypharmacology in Drug-Target Network
A current key feature in drug-target network is that drugs often bind to multiple targets, known as polypharmacology or drug promiscuity. Recent literature has indicated that relatively small fragments in both drugs and targets are crucial in forming polypharmacology. We hypothesize that principles...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044142/ https://www.ncbi.nlm.nih.gov/pubmed/21373195 http://dx.doi.org/10.1371/journal.pone.0016999 |