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Therapeutic Utility of Phosphodiesterase Type I Inhibitors in Neurological Conditions

Neuronal plasticity is an essential property of the brain that is impaired in different neurological conditions. Phosphodiesterase type 1 (PDE1) inhibitors can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and...

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Detalles Bibliográficos
Autor principal: Medina, Alexandre E.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044262/
https://www.ncbi.nlm.nih.gov/pubmed/21373359
http://dx.doi.org/10.3389/fnins.2011.00021