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The choice of null distributions for detecting gene-gene interactions in genome-wide association studies

BACKGROUND: In genome-wide association studies (GWAS), the number of single-nucleotide polymorphisms (SNPs) typically ranges between 500,000 and 1,000,000. Accordingly, detecting gene-gene interactions in GWAS is computationally challenging because it involves hundreds of billions of SNP pairs. Stag...

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Detalles Bibliográficos
Autores principales:	Yang, Can, Wan, Xiang, He, Zengyou, Yang, Qiang, Xue, Hong, Yu, Weichuan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044281/ https://www.ncbi.nlm.nih.gov/pubmed/21342556 http://dx.doi.org/10.1186/1471-2105-12-S1-S26

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