Functional characterization of novel mutations in UL54 of ganciclovir resistant HCMV strain using structural analysis

This study reports the probable impact of the coupled mutations observed in our clinical isolate of HCMV UL54 polymerase, through structural bioinformatics approaches. The reported variant was found to be resistant to Ganciclovir (GCV) as per the clinical records. The presence of Glutamine deletion...

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Detalles Bibliográficos
Autores principales: Malathi, Jambulingam, Umashankar, Vetrivel, Sathyabaarathi, Ravichandran, Muthukumaran, Sivashanmugan, Ishwarya, Murali, Madhavan, Hajib Narahari
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2011
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044428/
https://www.ncbi.nlm.nih.gov/pubmed/21383907

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