CTX-M β-Lactamase Production and Virulence of Escherichia coli K1

We report a patient with neonatal meningitis caused by a CTX-M-1–producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in cli...

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Detalles Bibliográficos
Autores principales: Dubois, Damien, Prasadarao, Nemani V., Mittal, Rahul, Bret, Laurent, Roujou-Gris, Marie, Bonnet, Richard
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2009
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044546/
https://www.ncbi.nlm.nih.gov/pubmed/19961682
http://dx.doi.org/10.3201/eid1512.090928
Descripción
Sumario:We report a patient with neonatal meningitis caused by a CTX-M-1–producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome.

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