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The Genotype of Early-Transmitting HIV gp120s Promotes α(4)β(7) –Reactivity, Revealing α(4)β(7) (+)/CD4(+) T cells As Key Targets in Mucosal Transmission
Mucosal transmission of HIV is inefficient. The virus must breach physical barriers before it infects mucosal CD4(+) T cells. Low-level viral replication occurs initially in mucosal CD4(+) T cells, but within days high-level replication occurs in Peyer's patches, the gut lamina propria and mese...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044691/ https://www.ncbi.nlm.nih.gov/pubmed/21383973 http://dx.doi.org/10.1371/journal.ppat.1001301 |