Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis

BACKGROUND: Severe sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic manipulation of death and survival pathways has been shown to modulate organ injury and survival. METHODOLOGY/PRINC...

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Detalles Bibliográficos
Autores principales: Iwata, Akiko, de Claro, R. Angelo, Morgan-Stevenson, Vicki L., Tupper, Joan C., Schwartz, Barbara R., Liu, Li, Zhu, Xiaodong, Jordan, Katherine C., Winn, Robert K., Harlan, John M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044724/
https://www.ncbi.nlm.nih.gov/pubmed/21390214
http://dx.doi.org/10.1371/journal.pone.0014729

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