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Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning: Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice

SCRAPPER, an F-box protein coded by FBXL20, is a subunit of SCF type E3 ubiquitin ligase. SCRAPPER localizes synapses and directly binds to Rab3-interacting molecule 1 (RIM1), an essential factor for synaptic vesicle release, thus it regulates neural transmission via RIM1 degradation. A defect in SC...

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Detalles Bibliográficos
Autores principales:	Yao, Ikuko, Takao, Keizo, Miyakawa, Tsuyoshi, Ito, Seiji, Setou, Mitsutoshi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044740/ https://www.ncbi.nlm.nih.gov/pubmed/21390313 http://dx.doi.org/10.1371/journal.pone.0017317

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