Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

Huntington's disease (HD), a genetic neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) protein, is accompanied by multiple mitochondrial alterations. Here, we show that mitochondrial fragmentation and cristae alterations characterize cellular models of HD and...

Descripción completa

Detalles Bibliográficos
Autores principales: Costa, Veronica, Giacomello, Marta, Hudec, Roman, Lopreiato, Raffaele, Ermak, Gennady, Lim, Dmitri, Malorni, Walter, Davies, Kelvin J A, Carafoli, Ernesto, Scorrano, Luca
Formato: Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044888/
https://www.ncbi.nlm.nih.gov/pubmed/21069748
http://dx.doi.org/10.1002/emmm.201000102

Ejemplares similares

Ejemplares similares