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The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS

Homodimerization is an essential step for membrane type 1 matrix metalloproteinase (MT1-MMP) to activate proMMP-2 and to degrade collagen on the cell surface. To uncover the molecular basis of the hemopexin (Hpx) domain-driven dimerization of MT1-MMP, a crystal structure of the Hpx domain was solved...

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Detalles Bibliográficos
Autores principales:	Tochowicz, Anna, Goettig, Peter, Evans, Richard, Visse, Robert, Shitomi, Yasuyuki, Palmisano, Ralf, Ito, Noriko, Richter, Klaus, Maskos, Klaus, Franke, Daniel, Svergun, Dmitri, Nagase, Hideaki, Bode, Wolfram, Itoh, Yoshifumi
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045013/ https://www.ncbi.nlm.nih.gov/pubmed/21193411 http://dx.doi.org/10.1074/jbc.M110.178434

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