Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-­ISA247 (voclosporin)

E-ISA247 (voclosporin) is a cyclosporin A analogue that is in late-stage clinical development for the treatment of autoimmune diseases and the prevention of organ graft rejection. The X-­ray crystal structures of E-ISA247 and its stereoisomer Z-­ISA247 bound to cyclophilin A have been determined and...

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Detalles Bibliográficos
Autores principales: Kuglstatter, Andreas, Mueller, Francis, Kusznir, Eric, Gsell, Bernard, Stihle, Martine, Thoma, Ralf, Benz, Joerg, Aspeslet, Launa, Freitag, Derrick, Hennig, Michael
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045272/
https://www.ncbi.nlm.nih.gov/pubmed/21245533
http://dx.doi.org/10.1107/S0907444910051905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045272/
https://www.ncbi.nlm.nih.gov/pubmed/21245533
http://dx.doi.org/10.1107/S0907444910051905

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