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Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)
E-ISA247 (voclosporin) is a cyclosporin A analogue that is in late-stage clinical development for the treatment of autoimmune diseases and the prevention of organ graft rejection. The X-ray crystal structures of E-ISA247 and its stereoisomer Z-ISA247 bound to cyclophilin A have been determined and...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045272/ https://www.ncbi.nlm.nih.gov/pubmed/21245533 http://dx.doi.org/10.1107/S0907444910051905 |