Exploring the Evolutionary Relationship of Insulin Receptor Substrate Family Using Computational Biology

Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the...

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Detalles Bibliográficos
Autores principales: Chakraborty, Chiranjib, Agoramoorthy, Govindasamy, Hsu, Minna J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045367/
https://www.ncbi.nlm.nih.gov/pubmed/21364910
http://dx.doi.org/10.1371/journal.pone.0016580
Descripción
Sumario:Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models.

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