Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease

Nicastrin is an obligatory component of the γ-secretase; the enzyme complex that leads to the production of Aβ fragments critically central to the pathogenesis of Alzheimer's disease (AD). Analyses of the effects of common variation in this gene on risk for late onset AD have been inconclusive....

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Detalles Bibliográficos
Autores principales: Lupton, Michelle K., Proitsi, Petroula, Danillidou, Makrina, Tsolaki, Magda, Hamilton, Gillian, Wroe, Richard, Pritchard, Megan, Lord, Kathryn, Martin, Belinda M., Kloszewska, Iwona, Soininen, Hilkka, Mecocci, Patrizia, Vellas, Bruno, Harold, Denise, Hollingworth, Paul, Lovestone, Simon, Powell, John F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045431/
https://www.ncbi.nlm.nih.gov/pubmed/21364883
http://dx.doi.org/10.1371/journal.pone.0017298

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