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Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator

Understanding the ecological, evolutionary and genetic factors that affect the expression of cooperative behaviours is a topic of wide biological significance. On a practical level, this field of research is useful because many pathogenic microbes rely on the cooperative production of public goods (...

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Detalles Bibliográficos
Autores principales: Harrison, Freya, Buckling, Angus
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045467/
https://www.ncbi.nlm.nih.gov/pubmed/21364773
http://dx.doi.org/10.1371/journal.pone.0017254
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author Harrison, Freya
Buckling, Angus
author_facet Harrison, Freya
Buckling, Angus
author_sort Harrison, Freya
collection PubMed
description Understanding the ecological, evolutionary and genetic factors that affect the expression of cooperative behaviours is a topic of wide biological significance. On a practical level, this field of research is useful because many pathogenic microbes rely on the cooperative production of public goods (such as nutrient scavenging molecules, toxins and biofilm matrix components) in order to exploit their hosts. Understanding the evolutionary dynamics of cooperation is particularly relevant when considering long-term, chronic infections where there is significant potential for intra-host evolution. The impact of responses to non-social selection pressures on social evolution is arguably an under-examined area. In this paper, we consider how the evolution of a non-social trait – hypermutability – affects the cooperative production of iron-scavenging siderophores by the opportunistic human pathogen Pseudomonas aeruginosa. We confirm an earlier prediction that hypermutability accelerates the breakdown of cooperation due to increased sampling of genotypic space, allowing mutator lineages to generate non-cooperative genotypes with the ability to persist at high frequency and dominate populations. This may represent a novel cost of hypermutability.
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spelling pubmed-30454672011-03-01 Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator Harrison, Freya Buckling, Angus PLoS One Research Article Understanding the ecological, evolutionary and genetic factors that affect the expression of cooperative behaviours is a topic of wide biological significance. On a practical level, this field of research is useful because many pathogenic microbes rely on the cooperative production of public goods (such as nutrient scavenging molecules, toxins and biofilm matrix components) in order to exploit their hosts. Understanding the evolutionary dynamics of cooperation is particularly relevant when considering long-term, chronic infections where there is significant potential for intra-host evolution. The impact of responses to non-social selection pressures on social evolution is arguably an under-examined area. In this paper, we consider how the evolution of a non-social trait – hypermutability – affects the cooperative production of iron-scavenging siderophores by the opportunistic human pathogen Pseudomonas aeruginosa. We confirm an earlier prediction that hypermutability accelerates the breakdown of cooperation due to increased sampling of genotypic space, allowing mutator lineages to generate non-cooperative genotypes with the ability to persist at high frequency and dominate populations. This may represent a novel cost of hypermutability. Public Library of Science 2011-02-25 /pmc/articles/PMC3045467/ /pubmed/21364773 http://dx.doi.org/10.1371/journal.pone.0017254 Text en Harrison, Buckling. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Harrison, Freya
Buckling, Angus
Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator
title Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator
title_full Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator
title_fullStr Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator
title_full_unstemmed Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator
title_short Wider Access to Genotypic Space Facilitates Loss of Cooperation in a Bacterial Mutator
title_sort wider access to genotypic space facilitates loss of cooperation in a bacterial mutator
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045467/
https://www.ncbi.nlm.nih.gov/pubmed/21364773
http://dx.doi.org/10.1371/journal.pone.0017254
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