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The Current State of Proteomics in GI Oncology
Proteomics refers to the study of the entire set of proteins in a given cell or tissue. With the extensive development of protein separation, mass spectrometry, and bioinformatics technologies, clinical proteomics has shown its potential as a powerful approach for biomarker discovery, particularly i...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer US
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045515/ https://www.ncbi.nlm.nih.gov/pubmed/19104933 http://dx.doi.org/10.1007/s10620-008-0656-5 |
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author | Lin, Ying Dynan, William S. Lee, Jeffrey R. Zhu, Zhao-Hua Schade, Robert R. |
author_facet | Lin, Ying Dynan, William S. Lee, Jeffrey R. Zhu, Zhao-Hua Schade, Robert R. |
author_sort | Lin, Ying |
collection | PubMed |
description | Proteomics refers to the study of the entire set of proteins in a given cell or tissue. With the extensive development of protein separation, mass spectrometry, and bioinformatics technologies, clinical proteomics has shown its potential as a powerful approach for biomarker discovery, particularly in the area of oncology. More than 130 exploratory studies have defined candidate markers in serum, gastrointestinal (GI) fluids, or cancer tissue. In this article, we introduce the commonly adopted proteomic technologies and describe results of a comprehensive review of studies that have applied these technologies to GI oncology, with a particular emphasis on developments in the last 3 years. We discuss reasons why the more than 130 studies to date have had little discernible clinical impact, and we outline steps that may allow proteomics to realize its promise for early detection of disease, monitoring of disease recurrence, and identification of targets for individualized therapy. |
format | Text |
id | pubmed-3045515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-30455152011-04-04 The Current State of Proteomics in GI Oncology Lin, Ying Dynan, William S. Lee, Jeffrey R. Zhu, Zhao-Hua Schade, Robert R. Dig Dis Sci Review Proteomics refers to the study of the entire set of proteins in a given cell or tissue. With the extensive development of protein separation, mass spectrometry, and bioinformatics technologies, clinical proteomics has shown its potential as a powerful approach for biomarker discovery, particularly in the area of oncology. More than 130 exploratory studies have defined candidate markers in serum, gastrointestinal (GI) fluids, or cancer tissue. In this article, we introduce the commonly adopted proteomic technologies and describe results of a comprehensive review of studies that have applied these technologies to GI oncology, with a particular emphasis on developments in the last 3 years. We discuss reasons why the more than 130 studies to date have had little discernible clinical impact, and we outline steps that may allow proteomics to realize its promise for early detection of disease, monitoring of disease recurrence, and identification of targets for individualized therapy. Springer US 2008-12-23 2009 /pmc/articles/PMC3045515/ /pubmed/19104933 http://dx.doi.org/10.1007/s10620-008-0656-5 Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Lin, Ying Dynan, William S. Lee, Jeffrey R. Zhu, Zhao-Hua Schade, Robert R. The Current State of Proteomics in GI Oncology |
title | The Current State of Proteomics in GI Oncology |
title_full | The Current State of Proteomics in GI Oncology |
title_fullStr | The Current State of Proteomics in GI Oncology |
title_full_unstemmed | The Current State of Proteomics in GI Oncology |
title_short | The Current State of Proteomics in GI Oncology |
title_sort | current state of proteomics in gi oncology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045515/ https://www.ncbi.nlm.nih.gov/pubmed/19104933 http://dx.doi.org/10.1007/s10620-008-0656-5 |
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