Cargando…
Fluorescence-based duplex–quadruplex competition test to screen for telomerase RNA quadruplex ligands
RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5′-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a key structural element for thi...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045579/ https://www.ncbi.nlm.nih.gov/pubmed/21106496 http://dx.doi.org/10.1093/nar/gkq1199 |