How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics

BACKGROUND: Cathepsin B (catB) is a promising target for anti-cancer drug design due to its implication in several steps of tumorigenesis. catB activity and inhibition are pH-dependent, making it difficult to identify efficient inhibitor candidates for clinical trials. In addition it is known that h...

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Detalles Bibliográficos
Autores principales: Costa, Mauricio GS, Batista, Paulo R, Shida, Cláudio S, Robert, Charles H, Bisch, Paulo M, Pascutti, Pedro G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045798/
https://www.ncbi.nlm.nih.gov/pubmed/21210971
http://dx.doi.org/10.1186/1471-2164-11-S5-S5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045798/
https://www.ncbi.nlm.nih.gov/pubmed/21210971
http://dx.doi.org/10.1186/1471-2164-11-S5-S5

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