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Solitary splenic metastasis from ovarian carcinosarcoma: a case report

INTRODUCTION: Metastatic tumors to the spleen are rare but are usually found in conjunction with metastasis to other organs. The most common sources of splenic metastasis are breast, lung and colorectal cancers as well as melanoma and ovarian carcinoma. A solitary carcinosarcoma metastasis to the sp...

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Autores principales: Olsen, Alex B, Pargman, Sabine, Gillespie, Thomas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045934/
https://www.ncbi.nlm.nih.gov/pubmed/21310035
http://dx.doi.org/10.1186/1752-1947-5-56
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author Olsen, Alex B
Pargman, Sabine
Gillespie, Thomas
author_facet Olsen, Alex B
Pargman, Sabine
Gillespie, Thomas
author_sort Olsen, Alex B
collection PubMed
description INTRODUCTION: Metastatic tumors to the spleen are rare but are usually found in conjunction with metastasis to other organs. The most common sources of splenic metastasis are breast, lung and colorectal cancers as well as melanoma and ovarian carcinoma. A solitary carcinosarcoma metastasis to the spleen of any origin is very rare. To the best of our knowledge, there are fewer than 30 reported cases of ovarian primary tumors with solitary metastasis to the spleen, and only three solitary primary carcinosarcomas to the spleen have been reported, of which one is female. We present what is, to the best of our knowledge, the first case of a solitary metastatic carcinosarcoma to the spleen arising from a primary ovarian carcinsarcoma. CASE PRESENTATION: A 72-year-old Hispanic woman status post-total abdominal hysterectomy for ovarian carcinosarcoma presented with complaints of early satiety and abdominal pain for the past two months with a 30-lb unintentional weight loss. An initial computed tomographic scan of her abdomen and pelvis revealed a 30 cm × 27 cm splenic mass with displacement of the left kidney, stomach and liver. The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma. CONCLUSION: Carcinosarcoma of the spleen is a rare tumor. Carcinosarcomas are a biphasic neoplasm comprising malignant epithelial and mesenchymal components arising from a stem cell capable of differentiation. They can arise anywhere in the female genital tract, most commonly from the endometrium. Even though it is rare, carcinosarcomas can metastasize to the spleen. This unique case of a solitary splenic metastasis from ovarian carcinosarcoma has particular interest in medicine, especially for the specialties of surgical oncology, pathology and hematology/oncology.
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spelling pubmed-30459342011-03-01 Solitary splenic metastasis from ovarian carcinosarcoma: a case report Olsen, Alex B Pargman, Sabine Gillespie, Thomas J Med Case Reports Case Report INTRODUCTION: Metastatic tumors to the spleen are rare but are usually found in conjunction with metastasis to other organs. The most common sources of splenic metastasis are breast, lung and colorectal cancers as well as melanoma and ovarian carcinoma. A solitary carcinosarcoma metastasis to the spleen of any origin is very rare. To the best of our knowledge, there are fewer than 30 reported cases of ovarian primary tumors with solitary metastasis to the spleen, and only three solitary primary carcinosarcomas to the spleen have been reported, of which one is female. We present what is, to the best of our knowledge, the first case of a solitary metastatic carcinosarcoma to the spleen arising from a primary ovarian carcinsarcoma. CASE PRESENTATION: A 72-year-old Hispanic woman status post-total abdominal hysterectomy for ovarian carcinosarcoma presented with complaints of early satiety and abdominal pain for the past two months with a 30-lb unintentional weight loss. An initial computed tomographic scan of her abdomen and pelvis revealed a 30 cm × 27 cm splenic mass with displacement of the left kidney, stomach and liver. The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma. CONCLUSION: Carcinosarcoma of the spleen is a rare tumor. Carcinosarcomas are a biphasic neoplasm comprising malignant epithelial and mesenchymal components arising from a stem cell capable of differentiation. They can arise anywhere in the female genital tract, most commonly from the endometrium. Even though it is rare, carcinosarcomas can metastasize to the spleen. This unique case of a solitary splenic metastasis from ovarian carcinosarcoma has particular interest in medicine, especially for the specialties of surgical oncology, pathology and hematology/oncology. BioMed Central 2011-02-10 /pmc/articles/PMC3045934/ /pubmed/21310035 http://dx.doi.org/10.1186/1752-1947-5-56 Text en Copyright ©2011 Olsen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Olsen, Alex B
Pargman, Sabine
Gillespie, Thomas
Solitary splenic metastasis from ovarian carcinosarcoma: a case report
title Solitary splenic metastasis from ovarian carcinosarcoma: a case report
title_full Solitary splenic metastasis from ovarian carcinosarcoma: a case report
title_fullStr Solitary splenic metastasis from ovarian carcinosarcoma: a case report
title_full_unstemmed Solitary splenic metastasis from ovarian carcinosarcoma: a case report
title_short Solitary splenic metastasis from ovarian carcinosarcoma: a case report
title_sort solitary splenic metastasis from ovarian carcinosarcoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045934/
https://www.ncbi.nlm.nih.gov/pubmed/21310035
http://dx.doi.org/10.1186/1752-1947-5-56
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