Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic Activity

During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors, thereby increasing the response to noxious stimuli. The relationship between NGF and pain is supported by genetic evidence: mutations in the NGF TrkA receptor in patients affected by an hereditary rare disease (Here...

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Detalles Bibliográficos
Autores principales: Capsoni, Simona, Covaceuszach, Sonia, Marinelli, Sara, Ceci, Marcello, Bernardo, Antonietta, Minghetti, Luisa, Ugolini, Gabriele, Pavone, Flaminia, Cattaneo, Antonino
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046150/
https://www.ncbi.nlm.nih.gov/pubmed/21387003
http://dx.doi.org/10.1371/journal.pone.0017321

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