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Predictions of Hot Spot Residues at Protein-Protein Interfaces Using Support Vector Machines
Protein-protein interactions are critically dependent on just a few ‘hot spot’ residues at the interface. Hot spots make a dominant contribution to the free energy of binding and they can disrupt the interaction if mutated to alanine. Here, we present HSPred, a support vector machine(SVM)-based meth...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046169/ https://www.ncbi.nlm.nih.gov/pubmed/21386962 http://dx.doi.org/10.1371/journal.pone.0016774 |