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Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
Human VRK1 induces a stabilization and accumulation of p53 by specific phosphorylation in Thr18. This p53 accumulation is reversed by its downregulation mediated by Hdm2, requiring a dephosphorylated p53 and therefore also needs the removal of VRK1 as stabilizer. This process requires export of VRK1...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046209/ https://www.ncbi.nlm.nih.gov/pubmed/21386980 http://dx.doi.org/10.1371/journal.pone.0017320 |