Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers

INTRODUCTION: The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and reflects the cell of origin of these tumors. However, approximately 20% of b...

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Detalles Bibliográficos
Autores principales: Tung, Nadine, Miron, Alexander, Schnitt, Stuart J, Gautam, Shiva, Fetten, Katharina, Kaplan, Jennifer, Yassin, Yosuf, Buraimoh, Ayodele, Kim, Ji-Young, Szász, Attila M, Tian, Ruiyang, Wang, Zhigang C, Collins, Laura C, Brock, Jane, Krag, Karen, Legare, Robert D, Sgroi, Dennis, Ryan, Paula D, Silver, Daniel P, Garber, Judy E, Richardson, Andrea L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046438/
https://www.ncbi.nlm.nih.gov/pubmed/21080930
http://dx.doi.org/10.1186/bcr2776

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