Cargando…

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

OBJECTIVE: We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both β-cell mass and function. RESEARCH DESIGN AND METHODS: Mice with β-cell–specific deletions of Ricto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Yanyun, Lindner, Jill, Kumar, Anil, Yuan, Weiping, Magnuson, Mark A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046843/ https://www.ncbi.nlm.nih.gov/pubmed/21266327 http://dx.doi.org/10.2337/db10-1194

Ejemplares similares

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan
por: Lamming, Dudley W, et al.
Publicado: (2014)

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors
por: Lee, Dongjun, et al.
Publicado: (2014)

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
por: Thomanetz, Venus, et al.
Publicado: (2013)

Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis()()
por: Schmidt, Katharina M., et al.
Publicado: (2018)

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
por: Kocalis, Heidi E., et al.
Publicado: (2014)

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
por: Zhang, Pili, et al.
Publicado: (2015)

The mTORC2 Component Rictor Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells
por: Im-aram, Akechai, et al.
Publicado: (2013)

Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
por: Zheng, Bei, et al.
Publicado: (2017)

microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells
por: Cui, Yan, et al.
Publicado: (2016)

MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
por: Artner, Isabella, et al.
Publicado: (2010)

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis
por: Li, Jianzhong, et al.
Publicado: (2015)

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
por: Spaeth, Jason M., et al.
Publicado: (2019)

Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models
por: Schmidt, Katharina M., et al.
Publicado: (2017)

TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2
por: Guo, Zheng, et al.
Publicado: (2021)

The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
por: Lewis, Karl J, et al.
Publicado: (2020)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma
por: Lu, Zhaoming, et al.
Publicado: (2020)

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43
por: Wang, Jia-dan, et al.
Publicado: (2021)

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
por: Chu, Qun, et al.
Publicado: (2022)

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
por: Benavides-Serrato, Angelica, et al.
Publicado: (2017)

PTH(1-34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway
por: Lv, Zhong, et al.
Publicado: (2020)

Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
por: Spaeth, Jason M., et al.
Publicado: (2017)

Correction to: mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
por: Chu, Qun, et al.
Publicado: (2022)

Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
por: Benavides-Serrato, Angelica, et al.
Publicado: (2019)

Retraction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
Publicado: (2023)

mTORC2 tips the balance in cell survival
por: Sedwick, Caitlin
Publicado: (2015)

Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
por: Ruicci, Kara M., et al.
Publicado: (2019)

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis
por: Han, Jaeseok, et al.
Publicado: (2015)

Islet-1 Is Essential for Pancreatic β-Cell Function
por: Ediger, Benjamin N., et al.
Publicado: (2014)

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2014)

Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression
por: Yasuda, Kunihiko, et al.
Publicado: (2015)

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma
por: Akgül, Seçkin, et al.
Publicado: (2018)

Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss
por: Fu, Xiaolong, et al.
Publicado: (2022)

Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells
por: Osipovich, Anna B., et al.
Publicado: (2020)

PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor
por: Bhattacharya, K, et al.
Publicado: (2016)

Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice
por: Piccand, Julie, et al.
Publicado: (2014)

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation
por: Kumar, Anil, et al.
Publicado: (2018)

Placental growth factor in beta cells plays an essential role in gestational beta-cell growth
por: Yang, Weixia, et al.
Publicado: (2020)

Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
por: Ruicci, Kara M., et al.
Publicado: (2019)

A Smad Signaling Network Regulates Islet Cell Proliferation
por: El-Gohary, Yousef, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_10idqvd456b95d6ti963e2ikfl