Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models

OBJECTIVE: Type 1 diabetes is an incurable chronic autoimmune disease. Although transplantation of pancreatic islets may serve as a surrogate source of insulin, recipients are subjected to a life of immunosuppression. Interleukin (IL)-21 is necessary for type 1 diabetes in NOD mice. We examined the...

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Detalles Bibliográficos
Autores principales: McGuire, Helen M., Walters, Stacey, Vogelzang, Alexis, Lee, Carol M.Y., Webster, Kylie E., Sprent, Jonathan, Christ, Daniel, Grey, Shane, King, Cecile
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046847/
https://www.ncbi.nlm.nih.gov/pubmed/21357471
http://dx.doi.org/10.2337/db10-1157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046847/
https://www.ncbi.nlm.nih.gov/pubmed/21357471
http://dx.doi.org/10.2337/db10-1157

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