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SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

OBJECTIVE: Inhibition of the Na(+)-glucose cotransporter type 2 (SGLT2) is currently being pursued as an insulin-independent treatment for diabetes; however, the behavioral and metabolic consequences of SGLT2 deletion are unknown. Here, we used a SGLT2 knockout mouse to investigate the effect of inc...

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Detalles Bibliográficos
Autores principales:	Jurczak, Michael J., Lee, Hui-Young, Birkenfeld, Andreas L., Jornayvaz, Francois R., Frederick, David W., Pongratz, Rebecca L., Zhao, Xiaoxian, Moeckel, Gilbert W., Samuel, Varman T., Whaley, Jean M., Shulman, Gerald I., Kibbey, Richard G.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046850/ https://www.ncbi.nlm.nih.gov/pubmed/21357472 http://dx.doi.org/10.2337/db10-1328

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