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Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of HIF-1α Expression and Oxygen Metabolism

OBJECTIVE: Chronic hypoxia has been recognized as a key regulator in renal tubulointerstitial fibrosis, as seen in diabetic nephropathy, which is associated with the activation of hypoxia-inducible factor (HIF)-1α. We assess here the effects of the biguanide, metformin, on the expression of HIF-1α i...

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Detalles Bibliográficos
Autores principales:	Takiyama, Yumi, Harumi, Tatsuo, Watanabe, Jun, Fujita, Yukihiro, Honjo, Jun, Shimizu, Norihiko, Makino, Yuichi, Haneda, Masakazu
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046859/ https://www.ncbi.nlm.nih.gov/pubmed/21282369 http://dx.doi.org/10.2337/db10-0655

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