Control of viral replication after cessation of HAART

We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation o...

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Detalles Bibliográficos
Autores principales: Van Gulck, Ellen, Heyndrickx, Leo, Bracke, Lotte, Coppens, Sandra, Florence, Eric, Buvé, Anne, Lewi, Paul, Vanham, Guido
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046910/
https://www.ncbi.nlm.nih.gov/pubmed/21314914
http://dx.doi.org/10.1186/1742-6405-8-6
Descripción
Sumario:We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders.

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