Control of viral replication after cessation of HAART

We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation o...

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Detalles Bibliográficos
Autores principales: Van Gulck, Ellen, Heyndrickx, Leo, Bracke, Lotte, Coppens, Sandra, Florence, Eric, Buvé, Anne, Lewi, Paul, Vanham, Guido
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046910/
https://www.ncbi.nlm.nih.gov/pubmed/21314914
http://dx.doi.org/10.1186/1742-6405-8-6
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author Van Gulck, Ellen
Heyndrickx, Leo
Bracke, Lotte
Coppens, Sandra
Florence, Eric
Buvé, Anne
Lewi, Paul
Vanham, Guido
author_facet Van Gulck, Ellen
Heyndrickx, Leo
Bracke, Lotte
Coppens, Sandra
Florence, Eric
Buvé, Anne
Lewi, Paul
Vanham, Guido
author_sort Van Gulck, Ellen
collection PubMed
description We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders.
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spelling pubmed-30469102011-03-02 Control of viral replication after cessation of HAART Van Gulck, Ellen Heyndrickx, Leo Bracke, Lotte Coppens, Sandra Florence, Eric Buvé, Anne Lewi, Paul Vanham, Guido AIDS Res Ther Case Report We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders. BioMed Central 2011-02-11 /pmc/articles/PMC3046910/ /pubmed/21314914 http://dx.doi.org/10.1186/1742-6405-8-6 Text en Copyright ©2011 Van Gulck et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Van Gulck, Ellen
Heyndrickx, Leo
Bracke, Lotte
Coppens, Sandra
Florence, Eric
Buvé, Anne
Lewi, Paul
Vanham, Guido
Control of viral replication after cessation of HAART
title Control of viral replication after cessation of HAART
title_full Control of viral replication after cessation of HAART
title_fullStr Control of viral replication after cessation of HAART
title_full_unstemmed Control of viral replication after cessation of HAART
title_short Control of viral replication after cessation of HAART
title_sort control of viral replication after cessation of haart
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046910/
https://www.ncbi.nlm.nih.gov/pubmed/21314914
http://dx.doi.org/10.1186/1742-6405-8-6
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