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Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques

BACKGROUND: A DNA prime, poxvirus (COPAK) boost vaccination regime with four antigens, i.e. a combination of two Plasmodium knowlesi sporozoite (csp/ssp2) and two blood stage (ama1/msp1(42)) genes, leads to self-limited parasitaemia in 60% of rhesus monkeys and survival from an otherwise lethal infe...

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Detalles Bibliográficos
Autores principales:	Mahdi Abdel Hamid, Muzamil, Remarque, Edmond J, El Hassan, Ibrahim M, Hussain, Ayman A, Narum, David L, Thomas, Alan W, Kocken, Clemens HM, Weiss, Walter R, Faber, Bart W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046915/ https://www.ncbi.nlm.nih.gov/pubmed/21303498 http://dx.doi.org/10.1186/1475-2875-10-29

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