Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease

BACKGROUND: Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common inherited and some sporadic forms of Parkinson's disease (PD). The molecular mechanism underlying the pathogenic role of LRRK2 mutations in PD remains unknown. METHODOLOGY/PRI...

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Detalles Bibliográficos
Autores principales: Li, Xianting, Wang, Qing Jun, Pan, Nina, Lee, Sangkyu, Zhao, Yingming, Chait, Brian T., Yue, Zhenyu
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046972/
https://www.ncbi.nlm.nih.gov/pubmed/21390248
http://dx.doi.org/10.1371/journal.pone.0017153

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