Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA ex...

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Detalles Bibliográficos
Autores principales: Sun, Wanpeng, Qiao, Ling, Liu, Qiang, Chen, Lifeng, Ling, Binbing, Sammynaiken, Ramaswami, Yang, Jian
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047081/
https://www.ncbi.nlm.nih.gov/pubmed/21369371
Descripción
Sumario:Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.

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