Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA ex...

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Autores principales: Sun, Wanpeng, Qiao, Ling, Liu, Qiang, Chen, Lifeng, Ling, Binbing, Sammynaiken, Ramaswami, Yang, Jian
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047081/
https://www.ncbi.nlm.nih.gov/pubmed/21369371
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author Sun, Wanpeng
Qiao, Ling
Liu, Qiang
Chen, Lifeng
Ling, Binbing
Sammynaiken, Ramaswami
Yang, Jian
author_facet Sun, Wanpeng
Qiao, Ling
Liu, Qiang
Chen, Lifeng
Ling, Binbing
Sammynaiken, Ramaswami
Yang, Jian
author_sort Sun, Wanpeng
collection PubMed
description Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
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spelling pubmed-30470812011-03-02 Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1 Sun, Wanpeng Qiao, Ling Liu, Qiang Chen, Lifeng Ling, Binbing Sammynaiken, Ramaswami Yang, Jian Int J Med Sci Short Research Communication Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity. Ivyspring International Publisher 2011-02-21 /pmc/articles/PMC3047081/ /pubmed/21369371 Text en © Ivyspring International Publisher. All rights reserved This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Short Research Communication
Sun, Wanpeng
Qiao, Ling
Liu, Qiang
Chen, Lifeng
Ling, Binbing
Sammynaiken, Ramaswami
Yang, Jian
Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
title Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
title_full Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
title_fullStr Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
title_full_unstemmed Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
title_short Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
title_sort anticancer activity of the pr domain of tumor suppressor riz1
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047081/
https://www.ncbi.nlm.nih.gov/pubmed/21369371
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AT liuqiang anticanceractivityoftheprdomainoftumorsuppressorriz1
AT chenlifeng anticanceractivityoftheprdomainoftumorsuppressorriz1
AT lingbinbing anticanceractivityoftheprdomainoftumorsuppressorriz1
AT sammynaikenramaswami anticanceractivityoftheprdomainoftumorsuppressorriz1
AT yangjian anticanceractivityoftheprdomainoftumorsuppressorriz1

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