Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive dept...

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Detalles Bibliográficos
Autores principales: Kuranov, Roman V., Qiu, Jinze, McElroy, Austin B., Estrada, Arnold, Salvaggio, Anthony, Kiel, Jeffrey, Dunn, Andrew K., Duong, Timothy Q., Milner, Thomas E.
Formato: Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Noninvasive Optical Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047355/
https://www.ncbi.nlm.nih.gov/pubmed/21412455
http://dx.doi.org/10.1364/BOE.2.000491
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author Kuranov, Roman V.
Qiu, Jinze
McElroy, Austin B.
Estrada, Arnold
Salvaggio, Anthony
Kiel, Jeffrey
Dunn, Andrew K.
Duong, Timothy Q.
Milner, Thomas E.
author_facet Kuranov, Roman V.
Qiu, Jinze
McElroy, Austin B.
Estrada, Arnold
Salvaggio, Anthony
Kiel, Jeffrey
Dunn, Andrew K.
Duong, Timothy Q.
Milner, Thomas E.
author_sort Kuranov, Roman V.
collection PubMed
description Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel phantom. DWP OCT SaO(2) is linearly correlated with blood-gas SaO(2) measurements. We demonstrate 6.3% precision in SaO(2) levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO(2) levels measured with DWP-OCT are identified and characterized.
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spelling pubmed-30473552011-03-16 Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography Kuranov, Roman V. Qiu, Jinze McElroy, Austin B. Estrada, Arnold Salvaggio, Anthony Kiel, Jeffrey Dunn, Andrew K. Duong, Timothy Q. Milner, Thomas E. Biomed Opt Express Noninvasive Optical Diagnostics Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel phantom. DWP OCT SaO(2) is linearly correlated with blood-gas SaO(2) measurements. We demonstrate 6.3% precision in SaO(2) levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO(2) levels measured with DWP-OCT are identified and characterized. Optical Society of America 2011-02-03 /pmc/articles/PMC3047355/ /pubmed/21412455 http://dx.doi.org/10.1364/BOE.2.000491 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Noninvasive Optical Diagnostics
Kuranov, Roman V.
Qiu, Jinze
McElroy, Austin B.
Estrada, Arnold
Salvaggio, Anthony
Kiel, Jeffrey
Dunn, Andrew K.
Duong, Timothy Q.
Milner, Thomas E.
Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
title Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
title_full Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
title_fullStr Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
title_full_unstemmed Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
title_short Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
title_sort depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (dwp) optical coherence tomography
topic Noninvasive Optical Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047355/
https://www.ncbi.nlm.nih.gov/pubmed/21412455
http://dx.doi.org/10.1364/BOE.2.000491
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