TACI triggers immunoglobulin class switching by activating B cells through the adaptor protein MyD88

BAFF and APRIL are innate immune mediators that trigger immunoglobulin (Ig) G and IgA class switch recombination (CSR) in B cells by engaging the receptor TACI. The mechanism underlying CSR signaling by TACI remains unknown. Here, we found that the cytoplasmic domain of TACI encompasses a conserved...

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Detalles Bibliográficos
Autores principales: He, Bing, Santamaria, Raul, Xu, Weifeng, Cols, Montserrat, Chen, Kang, Puga, Irene, Shan, Meimei, Xiong, Huabao, Bussel, James B., Chiu, April, Puel, Anne, Reichenbach, Jeanine, Marodi, László, Döffinger, Rainer, Vasconcelos, Julia, Issekutz, Andrew, Krause, Jens, Davies, Graham, Li, Xiaoxia, Grimbacher, Bodo, Plebani, Alessandro, Meffre, Eric, Picard, Capucine, Cunningham-Rundles, Charlotte, Casanova, Jean-Laurent, Cerutti, Andrea
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047500/
https://www.ncbi.nlm.nih.gov/pubmed/20676093
http://dx.doi.org/10.1038/ni.1914

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