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Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen

BACKGROUND: This report describes two cases with unexplained positive results for phencyclidine (PCP). AIMS: This case will correlate lamotrigine (Lamictal®) use with false-positive results for PCP on a rapid urine toxicology screen. METHODS: Case 1: A 62-year-old male arrived to the emergency depar...

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Autores principales: Geraci, Matthew J., Peele, James, McCoy, Stacey L., Elias, Brad
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047872/
https://www.ncbi.nlm.nih.gov/pubmed/21373301
http://dx.doi.org/10.1007/s12245-010-0235-3
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author Geraci, Matthew J.
Peele, James
McCoy, Stacey L.
Elias, Brad
author_facet Geraci, Matthew J.
Peele, James
McCoy, Stacey L.
Elias, Brad
author_sort Geraci, Matthew J.
collection PubMed
description BACKGROUND: This report describes two cases with unexplained positive results for phencyclidine (PCP). AIMS: This case will correlate lamotrigine (Lamictal®) use with false-positive results for PCP on a rapid urine toxicology screen. METHODS: Case 1: A 62-year-old male arrived to the emergency department in extreme psychosis. All positive results on the urine drug screen could be accounted for except PCP. A comprehensive drug screen was performed to confirm PCP use, but returned negative. PCP was ruled out as the causative agent. The reason for the PCP false positive remained unknown. Case 2: A 49-year-old female presented to the ED with a history of seizures and depression. Despite positive PCP results on a rapid urine drug screen, PCP use was ruled out due to patient presentation and comprehensive history. RESULTS: The differential diagnosis in case 1 included PCP abuse until PCP was ruled out by a comprehensive drug screen. A literature search failed to explain a reason for false-positive results. The patient in case 2 was not psychotic, but returned a positive urinalysis result for PCP. Case 2’s presentation combined with a comprehensive history at the facility ruled out PCP use. Both patients were taking the anti-seizure medication lamotrigine with nothing else in common. CONCLUSION: Lamotrigine has the potential to cause false-positive results for PCP on the Bio-Rad TOX/See urine toxicology screen.
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spelling pubmed-30478722011-03-03 Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen Geraci, Matthew J. Peele, James McCoy, Stacey L. Elias, Brad Int J Emerg Med Original Research Article BACKGROUND: This report describes two cases with unexplained positive results for phencyclidine (PCP). AIMS: This case will correlate lamotrigine (Lamictal®) use with false-positive results for PCP on a rapid urine toxicology screen. METHODS: Case 1: A 62-year-old male arrived to the emergency department in extreme psychosis. All positive results on the urine drug screen could be accounted for except PCP. A comprehensive drug screen was performed to confirm PCP use, but returned negative. PCP was ruled out as the causative agent. The reason for the PCP false positive remained unknown. Case 2: A 49-year-old female presented to the ED with a history of seizures and depression. Despite positive PCP results on a rapid urine drug screen, PCP use was ruled out due to patient presentation and comprehensive history. RESULTS: The differential diagnosis in case 1 included PCP abuse until PCP was ruled out by a comprehensive drug screen. A literature search failed to explain a reason for false-positive results. The patient in case 2 was not psychotic, but returned a positive urinalysis result for PCP. Case 2’s presentation combined with a comprehensive history at the facility ruled out PCP use. Both patients were taking the anti-seizure medication lamotrigine with nothing else in common. CONCLUSION: Lamotrigine has the potential to cause false-positive results for PCP on the Bio-Rad TOX/See urine toxicology screen. Springer-Verlag 2010-11-06 /pmc/articles/PMC3047872/ /pubmed/21373301 http://dx.doi.org/10.1007/s12245-010-0235-3 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Research Article
Geraci, Matthew J.
Peele, James
McCoy, Stacey L.
Elias, Brad
Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen
title Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen
title_full Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen
title_fullStr Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen
title_full_unstemmed Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen
title_short Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen
title_sort phencyclidine false positive induced by lamotrigine (lamictal®) on a rapid urine toxicology screen
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047872/
https://www.ncbi.nlm.nih.gov/pubmed/21373301
http://dx.doi.org/10.1007/s12245-010-0235-3
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