The effect of Helicobacter pylori on asthma and allergy

Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the...

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Autores principales: Amedei, Amedeo, Codolo, Gaia, Del Prete, Gianfranco, de Bernard, Marina, D’Elios, Mario M
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047919/
https://www.ncbi.nlm.nih.gov/pubmed/21437048
http://dx.doi.org/10.2147/JAA.S8971
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author Amedei, Amedeo
Codolo, Gaia
Del Prete, Gianfranco
de Bernard, Marina
D’Elios, Mario M
author_facet Amedei, Amedeo
Codolo, Gaia
Del Prete, Gianfranco
de Bernard, Marina
D’Elios, Mario M
author_sort Amedei, Amedeo
collection PubMed
description Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.
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spelling pubmed-30479192011-03-23 The effect of Helicobacter pylori on asthma and allergy Amedei, Amedeo Codolo, Gaia Del Prete, Gianfranco de Bernard, Marina D’Elios, Mario M J Asthma Allergy Review Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy. Dove Medical Press 2010-09-29 /pmc/articles/PMC3047919/ /pubmed/21437048 http://dx.doi.org/10.2147/JAA.S8971 Text en © 2010 Amedei et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Amedei, Amedeo
Codolo, Gaia
Del Prete, Gianfranco
de Bernard, Marina
D’Elios, Mario M
The effect of Helicobacter pylori on asthma and allergy
title The effect of Helicobacter pylori on asthma and allergy
title_full The effect of Helicobacter pylori on asthma and allergy
title_fullStr The effect of Helicobacter pylori on asthma and allergy
title_full_unstemmed The effect of Helicobacter pylori on asthma and allergy
title_short The effect of Helicobacter pylori on asthma and allergy
title_sort effect of helicobacter pylori on asthma and allergy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047919/
https://www.ncbi.nlm.nih.gov/pubmed/21437048
http://dx.doi.org/10.2147/JAA.S8971
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