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β-cell function is associated with metabolic syndrome in Mexican subjects
AIMS: The clinical diagnosis of metabolic syndrome does not find any parameters to evaluate the insulin sensitivity (IS) or β-cell function. The evaluation of these parameters would detect early risk of developing metabolic syndrome. The aim of this study is to determine the relationship between β-c...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047966/ https://www.ncbi.nlm.nih.gov/pubmed/21437099 http://dx.doi.org/10.2147/DMSOTT.S12375 |
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author | Baez-Duarte, Blanca G Sánchez-Guillén, María Del Carmen Pérez-Fuentes, Ricardo Zamora-Ginez, Irma Leon-Chavez, Bertha Alicia Revilla-Monsalve, Cristina Islas-Andrade, Sergio |
author_facet | Baez-Duarte, Blanca G Sánchez-Guillén, María Del Carmen Pérez-Fuentes, Ricardo Zamora-Ginez, Irma Leon-Chavez, Bertha Alicia Revilla-Monsalve, Cristina Islas-Andrade, Sergio |
author_sort | Baez-Duarte, Blanca G |
collection | PubMed |
description | AIMS: The clinical diagnosis of metabolic syndrome does not find any parameters to evaluate the insulin sensitivity (IS) or β-cell function. The evaluation of these parameters would detect early risk of developing metabolic syndrome. The aim of this study is to determine the relationship between β-cell function and presence of metabolic syndrome in Mexican subjects. MATERIAL AND METHODS: This study is part of the Mexican Survey on the Prevention of Diabetes (MexDiab Study) with headquarters in the city of Puebla, Mexico. The study comprised of 444 subjects of both genders, aged between 18 and 60 years and allocated into two study groups: (1) control group of individuals at metabolic balance without metabolic syndrome and (2) group composed of subjects with metabolic syndrome and diagnosed according to the criteria of the Third Report of the National Cholesterol Education Program Expert Panel on Defection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Anthropometric, biochemical, and clinical assessments were carried out. RESULTS: Average age of the subjects in the control group (n = 254) was 35.7 ± 11.5 years and 42.0 ± 10.7 years for subjects in the metabolic syndrome group (n = 190). Subjects at metabolic balance without metabolic syndrome showed decreased IS, increased insulin resistance (IR), and altered β-cell function. Individuals with metabolic syndrome showed a high prevalence (P ≤ 0.05) of family history of type 2 diabetes (T2D). This group also showed a significant metabolic imbalance with glucose and insulin levels and lipid profile outside the ranges considered safe to prevent the development of cardiovascular disease and T2D. CONCLUSION: The main finding in this study was the detection of altered β-cell function, decreased IS, an increased IR in subjects at metabolic balance, and the progressive deterioration of β-cell function and IS in subjects with metabolic syndrome as the number of features of metabolic syndrome increases. |
format | Text |
id | pubmed-3047966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30479662011-03-23 β-cell function is associated with metabolic syndrome in Mexican subjects Baez-Duarte, Blanca G Sánchez-Guillén, María Del Carmen Pérez-Fuentes, Ricardo Zamora-Ginez, Irma Leon-Chavez, Bertha Alicia Revilla-Monsalve, Cristina Islas-Andrade, Sergio Diabetes Metab Syndr Obes Original Research AIMS: The clinical diagnosis of metabolic syndrome does not find any parameters to evaluate the insulin sensitivity (IS) or β-cell function. The evaluation of these parameters would detect early risk of developing metabolic syndrome. The aim of this study is to determine the relationship between β-cell function and presence of metabolic syndrome in Mexican subjects. MATERIAL AND METHODS: This study is part of the Mexican Survey on the Prevention of Diabetes (MexDiab Study) with headquarters in the city of Puebla, Mexico. The study comprised of 444 subjects of both genders, aged between 18 and 60 years and allocated into two study groups: (1) control group of individuals at metabolic balance without metabolic syndrome and (2) group composed of subjects with metabolic syndrome and diagnosed according to the criteria of the Third Report of the National Cholesterol Education Program Expert Panel on Defection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Anthropometric, biochemical, and clinical assessments were carried out. RESULTS: Average age of the subjects in the control group (n = 254) was 35.7 ± 11.5 years and 42.0 ± 10.7 years for subjects in the metabolic syndrome group (n = 190). Subjects at metabolic balance without metabolic syndrome showed decreased IS, increased insulin resistance (IR), and altered β-cell function. Individuals with metabolic syndrome showed a high prevalence (P ≤ 0.05) of family history of type 2 diabetes (T2D). This group also showed a significant metabolic imbalance with glucose and insulin levels and lipid profile outside the ranges considered safe to prevent the development of cardiovascular disease and T2D. CONCLUSION: The main finding in this study was the detection of altered β-cell function, decreased IS, an increased IR in subjects at metabolic balance, and the progressive deterioration of β-cell function and IS in subjects with metabolic syndrome as the number of features of metabolic syndrome increases. Dove Medical Press 2010-08-30 /pmc/articles/PMC3047966/ /pubmed/21437099 http://dx.doi.org/10.2147/DMSOTT.S12375 Text en © 2010 Baez-Duarte et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Baez-Duarte, Blanca G Sánchez-Guillén, María Del Carmen Pérez-Fuentes, Ricardo Zamora-Ginez, Irma Leon-Chavez, Bertha Alicia Revilla-Monsalve, Cristina Islas-Andrade, Sergio β-cell function is associated with metabolic syndrome in Mexican subjects |
title | β-cell function is associated with metabolic syndrome in Mexican subjects |
title_full | β-cell function is associated with metabolic syndrome in Mexican subjects |
title_fullStr | β-cell function is associated with metabolic syndrome in Mexican subjects |
title_full_unstemmed | β-cell function is associated with metabolic syndrome in Mexican subjects |
title_short | β-cell function is associated with metabolic syndrome in Mexican subjects |
title_sort | β-cell function is associated with metabolic syndrome in mexican subjects |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047966/ https://www.ncbi.nlm.nih.gov/pubmed/21437099 http://dx.doi.org/10.2147/DMSOTT.S12375 |
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