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Management of gestational diabetes mellitus

The incidence of gestational diabetes mellitus (GDM) is on the increase and, if not diagnosed, managed and treated adequately, can have unfavorable maternal and fetal outcomes. Several studies have shown that glycemic values considered as adequate in the past when monitoring GDM failed to contain th...

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Detalles Bibliográficos
Autores principales: Lapolla, Annunziata, Dalfrà, Maria Grazia, Fedele, Domenico
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048015/
https://www.ncbi.nlm.nih.gov/pubmed/21437120
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author Lapolla, Annunziata
Dalfrà, Maria Grazia
Fedele, Domenico
author_facet Lapolla, Annunziata
Dalfrà, Maria Grazia
Fedele, Domenico
author_sort Lapolla, Annunziata
collection PubMed
description The incidence of gestational diabetes mellitus (GDM) is on the increase and, if not diagnosed, managed and treated adequately, can have unfavorable maternal and fetal outcomes. Several studies have shown that glycemic values considered as adequate in the past when monitoring GDM failed to contain these adverse outcomes and randomized trials are needed to ascertain whether these targets should be lowered. Dietary restrictions remain the mainstay of GDM management and suitable physical exercise can help too. The use of rapid-acting insulin analogues (lispro and aspart) are novel treatments for improving metabolic control by reducing postprandial glycemia, while long-acting insulin analogues need to be evaluated by further studies for safety in clinical use before they can be prescribed. Numerous studies have found glyburide and metformin safe in women with GDM but more randomized controlled trials are needed, with a long-term follow-up of mother and child, to confirm these results.
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spelling pubmed-30480152011-03-23 Management of gestational diabetes mellitus Lapolla, Annunziata Dalfrà, Maria Grazia Fedele, Domenico Diabetes Metab Syndr Obes Review The incidence of gestational diabetes mellitus (GDM) is on the increase and, if not diagnosed, managed and treated adequately, can have unfavorable maternal and fetal outcomes. Several studies have shown that glycemic values considered as adequate in the past when monitoring GDM failed to contain these adverse outcomes and randomized trials are needed to ascertain whether these targets should be lowered. Dietary restrictions remain the mainstay of GDM management and suitable physical exercise can help too. The use of rapid-acting insulin analogues (lispro and aspart) are novel treatments for improving metabolic control by reducing postprandial glycemia, while long-acting insulin analogues need to be evaluated by further studies for safety in clinical use before they can be prescribed. Numerous studies have found glyburide and metformin safe in women with GDM but more randomized controlled trials are needed, with a long-term follow-up of mother and child, to confirm these results. Dove Medical Press 2009-06-17 /pmc/articles/PMC3048015/ /pubmed/21437120 Text en © 2009 Lapolla et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Lapolla, Annunziata
Dalfrà, Maria Grazia
Fedele, Domenico
Management of gestational diabetes mellitus
title Management of gestational diabetes mellitus
title_full Management of gestational diabetes mellitus
title_fullStr Management of gestational diabetes mellitus
title_full_unstemmed Management of gestational diabetes mellitus
title_short Management of gestational diabetes mellitus
title_sort management of gestational diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048015/
https://www.ncbi.nlm.nih.gov/pubmed/21437120
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