MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression

Recombinant adeno-associated viruses (rAAVs) that can cross the blood–brain-barrier and achieve efficient and stable transvascular gene transfer to the central nervous system (CNS) hold significant promise for treating CNS disorders. However, following intravascular delivery, these vectors also targ...

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Detalles Bibliográficos
Autores principales: Xie, Jun, Xie, Qing, Zhang, Hongwei, Ameres, Stefan L, Hung, Jui-Hung, Su, Qin, He, Ran, Mu, Xin, Seher Ahmed, Seemin, Park, Soyeon, Kato, Hiroki, Li, Chengjian, Mueller, Christian, Mello, Craig C, Weng, Zhiping, Flotte, Terence R, Zamore, Phillip D, Gao, Guangping
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048189/
https://www.ncbi.nlm.nih.gov/pubmed/21179009
http://dx.doi.org/10.1038/mt.2010.279

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