Mammographic density and its interaction with other breast cancer risk factors in an Asian population

BACKGROUND: Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS: From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic reg...

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Autores principales: Wong, C S, Lim, G H, Gao, F, Jakes, R W, Offman, J, Chia, K S, Duffy, S W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048202/
https://www.ncbi.nlm.nih.gov/pubmed/21245860
http://dx.doi.org/10.1038/sj.bjc.6606085
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author Wong, C S
Lim, G H
Gao, F
Jakes, R W
Offman, J
Chia, K S
Duffy, S W
author_facet Wong, C S
Lim, G H
Gao, F
Jakes, R W
Offman, J
Chia, K S
Duffy, S W
author_sort Wong, C S
collection PubMed
description BACKGROUND: Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS: From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS: Density was a significant risk factor, adjusting for other factors. Density of 76–100% had an odds ratio of 5.54 (95% CI 2.38–12.90) compared with 0–10%. Density had significant interactions with body mass index and oral contraceptive use (P=0.02). CONCLUSIONS: Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs.
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spelling pubmed-30482022012-03-01 Mammographic density and its interaction with other breast cancer risk factors in an Asian population Wong, C S Lim, G H Gao, F Jakes, R W Offman, J Chia, K S Duffy, S W Br J Cancer Short Communication BACKGROUND: Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS: From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS: Density was a significant risk factor, adjusting for other factors. Density of 76–100% had an odds ratio of 5.54 (95% CI 2.38–12.90) compared with 0–10%. Density had significant interactions with body mass index and oral contraceptive use (P=0.02). CONCLUSIONS: Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs. Nature Publishing Group 2011-03-01 2011-01-18 /pmc/articles/PMC3048202/ /pubmed/21245860 http://dx.doi.org/10.1038/sj.bjc.6606085 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Wong, C S
Lim, G H
Gao, F
Jakes, R W
Offman, J
Chia, K S
Duffy, S W
Mammographic density and its interaction with other breast cancer risk factors in an Asian population
title Mammographic density and its interaction with other breast cancer risk factors in an Asian population
title_full Mammographic density and its interaction with other breast cancer risk factors in an Asian population
title_fullStr Mammographic density and its interaction with other breast cancer risk factors in an Asian population
title_full_unstemmed Mammographic density and its interaction with other breast cancer risk factors in an Asian population
title_short Mammographic density and its interaction with other breast cancer risk factors in an Asian population
title_sort mammographic density and its interaction with other breast cancer risk factors in an asian population
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048202/
https://www.ncbi.nlm.nih.gov/pubmed/21245860
http://dx.doi.org/10.1038/sj.bjc.6606085
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