HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

BACKGROUND: Tumour stromal cells differ from its normal counterpart. We have shown that tumour endothelial cells (TECs) isolated from tumour tissues are also abnormal. Furthermore, we found that mRNAs of vascular endothelial growth factor-A (VEGF-A) and cyclooxygenase-2 (COX-2) were upregulated in T...

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Detalles Bibliográficos
Autores principales: Kurosu, T, Ohga, N, Hida, Y, Maishi, N, Akiyama, K, Kakuguchi, W, Kuroshima, T, Kondo, M, Akino, T, Totsuka, Y, Shindoh, M, Higashino, F, Hida, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048211/
https://www.ncbi.nlm.nih.gov/pubmed/21285980
http://dx.doi.org/10.1038/bjc.2011.20

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