FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

Fused in Sarcoma (FUS) proteinopathy is a feature of frontotemporal lobar dementia (FTLD), and mutation of the fus gene segregates with FTLD and amyotrophic lateral sclerosis (ALS). To study the consequences of mutation in the fus gene, we created transgenic rats expressing the human fus gene with o...

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Detalles Bibliográficos
Autores principales: Huang, Cao, Zhou, Hongxia, Tong, Jianbin, Chen, Han, Liu, Yong-Jian, Wang, Dian, Wei, Xiaotao, Xia, Xu-Gang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048370/
https://www.ncbi.nlm.nih.gov/pubmed/21408206
http://dx.doi.org/10.1371/journal.pgen.1002011

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