Initial Mutations Direct Alternative Pathways of Protein Evolution

Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e. non-additive interaction between mutations that affect fitness) is a mechanism that can contribute to both scenarios. Epistasis can co...

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Detalles Bibliográficos
Autores principales: Salverda, Merijn L. M., Dellus, Eynat, Gorter, Florien A., Debets, Alfons J. M., van der Oost, John, Hoekstra, Rolf F., Tawfik, Dan S., de Visser, J. Arjan G. M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048372/
https://www.ncbi.nlm.nih.gov/pubmed/21408208
http://dx.doi.org/10.1371/journal.pgen.1001321

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