SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1–Mediated DNA Damage and Genome Instability

Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated proteins and driving their proteasomal destruction. Here, we identify a critical function for fission yeast STUbL in suppressing spontaneous and...

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Detalles Bibliográficos
Autores principales: Heideker, Johanna, Prudden, John, Perry, J. Jefferson P., Tainer, John A., Boddy, Michael N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048374/
https://www.ncbi.nlm.nih.gov/pubmed/21408210
http://dx.doi.org/10.1371/journal.pgen.1001320

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