A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator

BACKGROUND: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. METHODOLOGY/PRINCIPAL FINDINGS: Employing independen...

Descripción completa

Detalles Bibliográficos
Autores principales: El Baroudi, Mariama, Corà, Davide, Bosia, Carla, Osella, Matteo, Caselle, Michele
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048388/
https://www.ncbi.nlm.nih.gov/pubmed/21390222
http://dx.doi.org/10.1371/journal.pone.0014742
_version_ 1782199152335126528
author El Baroudi, Mariama
Corà, Davide
Bosia, Carla
Osella, Matteo
Caselle, Michele
author_facet El Baroudi, Mariama
Corà, Davide
Bosia, Carla
Osella, Matteo
Caselle, Michele
author_sort El Baroudi, Mariama
collection PubMed
description BACKGROUND: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. METHODOLOGY/PRINCIPAL FINDINGS: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. CONCLUSIONS/SIGNIFICANCE: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.
format Text
id pubmed-3048388
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-30483882011-03-09 A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator El Baroudi, Mariama Corà, Davide Bosia, Carla Osella, Matteo Caselle, Michele PLoS One Research Article BACKGROUND: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. METHODOLOGY/PRINCIPAL FINDINGS: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. CONCLUSIONS/SIGNIFICANCE: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions. Public Library of Science 2011-03-03 /pmc/articles/PMC3048388/ /pubmed/21390222 http://dx.doi.org/10.1371/journal.pone.0014742 Text en El Baroudi et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
El Baroudi, Mariama
Corà, Davide
Bosia, Carla
Osella, Matteo
Caselle, Michele
A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator
title A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator
title_full A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator
title_fullStr A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator
title_full_unstemmed A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator
title_short A Curated Database of miRNA Mediated Feed-Forward Loops Involving MYC as Master Regulator
title_sort curated database of mirna mediated feed-forward loops involving myc as master regulator
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048388/
https://www.ncbi.nlm.nih.gov/pubmed/21390222
http://dx.doi.org/10.1371/journal.pone.0014742
work_keys_str_mv AT elbaroudimariama acurateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT coradavide acurateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT bosiacarla acurateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT osellamatteo acurateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT casellemichele acurateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT elbaroudimariama curateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT coradavide curateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT bosiacarla curateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT osellamatteo curateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator
AT casellemichele curateddatabaseofmirnamediatedfeedforwardloopsinvolvingmycasmasterregulator

Ejemplares similares