A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis

BACKGROUND: Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. During G1 and S and in cellular response to DNA damage, Cdc25A is targeted for d...

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Detalles Bibliográficos
Autores principales: Bahassi, El Mustapha, Yin, Moying, Robbins, Susan B, Li, Ya-Qin, Conrady, Deborah G, Yuan, Zhenyu, Kovall, Rhett A, Herr, Andrew B, Stambrook, Peter J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048473/
https://www.ncbi.nlm.nih.gov/pubmed/21310058
http://dx.doi.org/10.1186/1747-1028-6-4

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