Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy

BACKGROUND: Genetic fusion of the major birch pollen allergen (Bet v1) to bacterial surface-(S)-layer proteins resulted in recombinant proteins exhibiting reduced allergenicity as well as immunomodulatory capacity. Thus, S-layer/allergen fusion proteins were considered as suitable carriers for new i...

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Detalles Bibliográficos
Autores principales: Ilk, Nicola, Schumi, Christian-Thomas, Bohle, Barbara, Egelseer, Eva Maria, Sleytr, Uwe B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048495/
https://www.ncbi.nlm.nih.gov/pubmed/21310062
http://dx.doi.org/10.1186/1475-2859-10-6

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