Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6

A 7 amino acid deletion in Gag p6 (P6delta7) emerged in Chinese prevalent HIV-1 strain CRF07_BC from different epidemic regions. It is important to determine whether this mutation could be transmitted and spread. In this study, HIV-1 Gag sequences from 5 different epidemic regions in China were coll...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhefeng, Meng, Huiliang, Hu, Chao, Qiu, Jun, Sun, Jianxin, Lu, Xiaoyan, Zhang, Jianqing, Xu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048562/
https://www.ncbi.nlm.nih.gov/pubmed/21306651
http://dx.doi.org/10.1186/1743-422X-8-60
_version_ 1782199178493952000
author Zhefeng, Meng
Huiliang, Hu
Chao, Qiu
Jun, Sun
Jianxin, Lu
Xiaoyan, Zhang
Jianqing, Xu
author_facet Zhefeng, Meng
Huiliang, Hu
Chao, Qiu
Jun, Sun
Jianxin, Lu
Xiaoyan, Zhang
Jianqing, Xu
author_sort Zhefeng, Meng
collection PubMed
description A 7 amino acid deletion in Gag p6 (P6delta7) emerged in Chinese prevalent HIV-1 strain CRF07_BC from different epidemic regions. It is important to determine whether this mutation could be transmitted and spread. In this study, HIV-1 Gag sequences from 5 different epidemic regions in China were collected to trace the transmission linkage and to analyze genetic evolution of P6delta7 strains. The sequence analysis demonstrated that P6delta7 is a CRF07_BC specific deletion, different P6delta7 strains could be originated from different parental CRF07_BC recombinants in different epidemic regions, and the transmission of P6delta7 strain has occurred in IDU populations. This is for the first time to identify the transmission linkage for P6delta7 strains and serves as a wake-up call for further monitoring in the future; In addition, P6delta7 deletion may represent an evolutionary feature which might exert influence on the fitness of CRF07_BC strain.
format Text
id pubmed-3048562
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30485622011-03-05 Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6 Zhefeng, Meng Huiliang, Hu Chao, Qiu Jun, Sun Jianxin, Lu Xiaoyan, Zhang Jianqing, Xu Virol J Short Report A 7 amino acid deletion in Gag p6 (P6delta7) emerged in Chinese prevalent HIV-1 strain CRF07_BC from different epidemic regions. It is important to determine whether this mutation could be transmitted and spread. In this study, HIV-1 Gag sequences from 5 different epidemic regions in China were collected to trace the transmission linkage and to analyze genetic evolution of P6delta7 strains. The sequence analysis demonstrated that P6delta7 is a CRF07_BC specific deletion, different P6delta7 strains could be originated from different parental CRF07_BC recombinants in different epidemic regions, and the transmission of P6delta7 strain has occurred in IDU populations. This is for the first time to identify the transmission linkage for P6delta7 strains and serves as a wake-up call for further monitoring in the future; In addition, P6delta7 deletion may represent an evolutionary feature which might exert influence on the fitness of CRF07_BC strain. BioMed Central 2011-02-10 /pmc/articles/PMC3048562/ /pubmed/21306651 http://dx.doi.org/10.1186/1743-422X-8-60 Text en Copyright ©2011 Zhefeng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Zhefeng, Meng
Huiliang, Hu
Chao, Qiu
Jun, Sun
Jianxin, Lu
Xiaoyan, Zhang
Jianqing, Xu
Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
title Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
title_full Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
title_fullStr Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
title_full_unstemmed Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
title_short Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
title_sort transmission of new crf07_bc strains with 7 amino acid deletion in gag p6
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048562/
https://www.ncbi.nlm.nih.gov/pubmed/21306651
http://dx.doi.org/10.1186/1743-422X-8-60
work_keys_str_mv AT zhefengmeng transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6
AT huilianghu transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6
AT chaoqiu transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6
AT junsun transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6
AT jianxinlu transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6
AT xiaoyanzhang transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6
AT jianqingxu transmissionofnewcrf07bcstrainswith7aminoaciddeletioningagp6

Ejemplares similares