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Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review

In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy i...

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Autores principales: Di Lorenzo, Gabriele, D’Alcamo, Alberto, Rizzo, Manfredi, Leto-Barone, Maria Stefania, Bianco, Claudia Lo, Ditta, Vito, Politi, Donatella, Castello, Francesco, Pepe, Ilenia, Di Fede, Gaetana, Rini, GiovamBattista
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048602/
https://www.ncbi.nlm.nih.gov/pubmed/21437139
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author Di Lorenzo, Gabriele
D’Alcamo, Alberto
Rizzo, Manfredi
Leto-Barone, Maria Stefania
Bianco, Claudia Lo
Ditta, Vito
Politi, Donatella
Castello, Francesco
Pepe, Ilenia
Di Fede, Gaetana
Rini, GiovamBattista
author_facet Di Lorenzo, Gabriele
D’Alcamo, Alberto
Rizzo, Manfredi
Leto-Barone, Maria Stefania
Bianco, Claudia Lo
Ditta, Vito
Politi, Donatella
Castello, Francesco
Pepe, Ilenia
Di Fede, Gaetana
Rini, GiovamBattista
author_sort Di Lorenzo, Gabriele
collection PubMed
description In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma and in rhinitis with asthma. We searched MEDLINE database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin (ASA) or food additive hypersensitivity or with autoreactivity to intradermal serum injection (ASST) when taken with an antihistamine but not in mild or moderate chronic idiopathic urticaria [urticaria without any possible secondary causes (ie, food additive or ASA and other NSAID hypersensitivity, or ASST)]. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angioedema, and exercise-induced anaphylaxis.
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spelling pubmed-30486022011-03-23 Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review Di Lorenzo, Gabriele D’Alcamo, Alberto Rizzo, Manfredi Leto-Barone, Maria Stefania Bianco, Claudia Lo Ditta, Vito Politi, Donatella Castello, Francesco Pepe, Ilenia Di Fede, Gaetana Rini, GiovamBattista J Asthma Allergy Review In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma and in rhinitis with asthma. We searched MEDLINE database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin (ASA) or food additive hypersensitivity or with autoreactivity to intradermal serum injection (ASST) when taken with an antihistamine but not in mild or moderate chronic idiopathic urticaria [urticaria without any possible secondary causes (ie, food additive or ASA and other NSAID hypersensitivity, or ASST)]. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angioedema, and exercise-induced anaphylaxis. Dove Medical Press 2008-12-09 /pmc/articles/PMC3048602/ /pubmed/21437139 Text en © 2009 Di Lorenzo et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Di Lorenzo, Gabriele
D’Alcamo, Alberto
Rizzo, Manfredi
Leto-Barone, Maria Stefania
Bianco, Claudia Lo
Ditta, Vito
Politi, Donatella
Castello, Francesco
Pepe, Ilenia
Di Fede, Gaetana
Rini, GiovamBattista
Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
title Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
title_full Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
title_fullStr Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
title_full_unstemmed Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
title_short Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
title_sort leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048602/
https://www.ncbi.nlm.nih.gov/pubmed/21437139
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